CB&Q, used extensively the E series for their Twin Cities, Denver, California and other Zephyrs, i.e., KC Zephyrs. On Denver Zephyrs, they used only two units, typically A & B, or A & A. Early 60's, prior to Amtrack, we would see the DZ and CZ pulled by three units of the E series, usually all "A" units.
When each of the various Zephyrs arrived back in Chicago, all "A" units were dispatched to commuter operations through out the day/night, pulling the heavy double decker commuter consists, each pulled by one unit only. Course each rotated back to the Zephyrs runs, as dispatchers warranted/scheduled.
Rode on one DZ that was in two sections, due to Annual Boy Scouts Jamboree, held in Denver some years. Both consists, were powered by three E Locomotives each, both sections never further apart from each other an hour, if that long.
The Budd passenger care were not as heavy as the old tri-axle'd standards and Pullmans, but they were not lightweights either, as the
Vista Domes (CZ - 5 ea. DZ up to 4 ea., and the TCZ often carried 4 ea.) were heavier than the standard Budd coaches/sleepers/diner cars, to lower the CG's.
My recollections of the EMD E series, from the E3, E5 all the way to E9's, never saw them employed in freight operations, as the "Q" had ample inventories of Geeps, and the SD series of freight engines during that era.
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